Scientific agreement on climate change has strengthened over the past few decades, with around 97% of publishing climate scientists agreeing that human activity is causing global warming. While scientific understanding has strengthened, a small but persistent proportion of the public actively opposes the mainstream scientific position. A number of factors contribute to this rejection of scientific evidence, with political ideology playing a key role. Conservative think tanks, supported with funding from vested interests, have been and continue to be a prolific source of misinformation about climate change. A major strategy by opponents of climate mitigation policies has been to cast doubt on the level of scientific agreement on climate change, contributing to the gap between public perception of scientific agreement and the 97% expert consensus. This “consensus gap” decreases public support for mitigation policies, demonstrating that misconceptions can have significant societal consequences. While scientists need to communicate the consensus, they also need to be aware of the fact that misinformation can interfere with the communication of accurate scientific information. As a consequence, neutralizing the influence of misinformation is necessary. Two approaches to neutralize misinformation involve refuting myths after they have been received by recipients (debunking) or preemptively inoculating people before they receive misinformation (prebunking). Research indicates preemptive refutation or “prebunking” is more effective than debunking in reducing the influence of misinformation. Guidelines to practically implement responses (both preemptive and reactive) can be found in educational research, cognitive psychology, and a branch of psychological research known as inoculation theory. Synthesizing these separate lines of research yields a coherent set of recommendations for educators and communicators. Clearly communicating scientific concepts, such as the scientific consensus, is important, but scientific explanations should be coupled with inoculating explanations of how that science can be distorted.