Immune cell infiltration in colonic cancer: correlation between biopsy and surgical specimens

Author:

Bordry N1ORCID,Germann M2,Foukas P G3,Sempoux C4,Yan P4,Dormond O5,Speiser D E6,Demartines N5,Sauvain M -O57

Affiliation:

1. Department of Oncology, University Hospital of Geneva, Geneva, Switzerland

2. Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

3. Second Department of Pathology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece

4. Institute of Pathology, Lausanne University Hospital Centre and University of Lausanne, Lausanne, Switzerland

5. Department of Visceral Surgery, Lausanne University Hospital Centre and University of Lausanne, Lausanne, Switzerland

6. Department of Oncology, University of Lausanne, Lausanne, Switzerland

7. Service de Chirurgie, Réseau Hospitalier Neuchâtelois, Neuchâtel, Switzerland

Abstract

Infiltration of CD3+ and CD8+ T cells in tumour biopsies of patients with colonic cancer correlated positively with CD3+ and CD8+ T cell infiltration in matched tumour surgical specimens. This opens new perspectives in the potential of tumour biopsies for prognosis and treatment decisions.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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