Evidence Should Trump Intuition by Preferring Inbred Strains to Outbred Stocks in Preclinical Research
Author:
Publisher
Oxford University Press (OUP)
Subject
General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine
Link
http://academic.oup.com/ilarjournal/article-pdf/55/3/399/1808649/ilu036.pdf
Reference20 articles.
1. Genetic Variation and Population Substructure in Outbred CD-1 Mice: Implications for Genome-Wide Association Studies
2. The origins and uses of mouse outbred stocks
3. Phenotypic variability of inbred and outbred mice
4. Use of a multistrain assay could improve the NTP carcinogenesis bioassay.
5. Inbred Strains Should Replace Outbred Stocks in Toxicology, Safety Testing, and Drug Development
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