QTLViewer: an interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations-Reference-Cited by-同舟云学术

QTLViewer: an interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations

Published:2022-06-15 Issue:8 Volume:12 Page:
ISSN:2160-1836
Container-title:G3 Genes|Genomes|Genetics
language:en
Short-container-title:

Author:

Vincent Matthew¹^ORCID,Gerdes Gyuricza Isabela¹^ORCID,Keele Gregory R¹^ORCID,Gatti Daniel M¹^ORCID,Keller Mark P²^ORCID,Broman Karl W³^ORCID,Churchill Gary A¹^ORCID

Affiliation:

1. The Jackson Laboratory , Bar Harbor, ME 04609, USA

2. Department of Biochemistry, University of Wisconsin–Madison , Madison, WI 53706-1544, USA

3. Department of Biostatistics and Medical Informatics, University of Wisconsin–Madison , Madison, WI 53706-1544, USA

Abstract

Abstract The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50 M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which can present a barrier to access for some researchers. The QTLViewer software allows users to graphically explore Collaborative Cross and Diversity Outbred quantitative trait locus mapping and related analyses performed through the R/qtl2 package. Additionally, the QTLViewer website serves as a repository for published Collaborative Cross and Diversity Outbred studies, increasing the accessibility of these genetic resources to the broader scientific community.

Funder

Jackson Laboratory Cube Initiative and grant funding from the National Institute of Health

University of Wisconsin–Madison, Department of Biochemistry and Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology

Link

https://academic.oup.com/g3journal/advance-article-pdf/doi/10.1093/g3journal/jkac146/44152786/jkac146.pdf

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