A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis

Author:

Munz Matthias12,Willenborg Christina2,Richter Gesa M1,Jockel-Schneider Yvonne3,Graetz Christian4,Staufenbiel Ingmar5,Wellmann Jürgen6,Berger Klaus6,Krone Bastian7,Hoffmann Per89,van der Velde Nathalie1011,Uitterlinden André G10,de Groot Lisette C P G M12,Sawalha Amr H1314,Direskeneli Haner15,Saruhan-Direskeneli Güher16,Guzeldemir-Akcakanat Esra17,Keceli Huseyin Gencay18,Laudes Matthias19,Noack Barbara20,Teumer Alexander21,Holtfreter Birte22,Kocher Thomas22,Eickholz Peter23,Meyle Jörg24,Doerfer Christof4,Bruckmann Corinna25,Lieb Wolfgang26,Franke Andre27,Schreiber Stefan1927,Nohutcu Rahime M17,Erdmann Jeanette2,Loos Bruno G28,Jepsen Soeren29,Dommisch Henrik1,Schaefer Arne S1

Affiliation:

1. Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité – University Medicine Berlin, Germany

2. Institute for Integrative and Experimental Genomics, University Medical Center Schleswig-Holstein - Campus Lübeck, Germany

3. Department of Periodontology, Clinic of Preventive Dentistry and Periodontology, University Medical Center of the Julius-Maximilians-University, Würzburg, Germany

4. Department of Operative Dentistry and Periodontology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany

5. Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, Hannover, Germany

6. Institute of Epidemiology and Social Medicine, University Münster, Germany

7. Institute of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Germany

8. Institute of Human Genetics, University of Bonn, Germany

9. Human Genomics Research Group, Department of Biomedicine, University Hospital of Basel, Switzerland

10. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

11. Department of Internal Medicine Section of Geriatrics, Amsterdam Medical Center, Amsterdam, The Netherlands

12. Department of Epidemiology and the EMGO Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

13. Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

14. Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, USA

15. Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

16. Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

17. Department of Periodontology, Faculty of Dentistry, Kocaeli University, Turkey

18. Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sihhiye, Ankara, Turkey

19. Clinic of Internal Medicine, University Clinic Schleswig-Holstein, Kiel, Germany

20. Clinic of Conservational Dentistry, Center of Dental, Oral and Maxillary Medicine, University Medical Center Carl-Gustav-Carus, Technical University Dresden, Germany

21. Institute for Community Medicine, University Medicine Greifswald, Germany

22. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Germany

23. Department of Periodontology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany

24. Department of Periodontology, University Medical Center Giessen and Marburg, Germany

25. Department of Conservative Dentistry and Periodontology, Medical University Vienna, School of Dentistry, Vienna, Austria

26. Institute of Epidemiology, Biobank PopGen, Christian-Albrechts-University, Kiel, Germany

27. Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany

28. Department of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, The Netherlands

29. Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany

Funder

The German Research Foundation DFG

Deutsche Forschungsgemeinschaft

German Ministry of Education and Research

The Dortmund Health Study (DHS)

German Migraine & Headache Society (DMKG)

Institute of Epidemiology and Social Medicine University of Muenster

German Ministry of Research and Education

BMBF

Federal Ministry of Education and Research BMBF

German Ministry of Education and Science

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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