Ceftazidime/avibactam resistance associated with L169P mutation in the omega loop of KPC-2
Author:
Affiliation:
1. Los Angeles Department of Public Health, Downey, CA, USA
2. Accelerate Diagnostics, Tucson, AZ, USA
3. Department of Pathology, University of Arizona, Tucson, AZ, USA
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)
Link
http://academic.oup.com/jac/article-pdf/74/5/1241/28501293/dkz026.pdf
Reference13 articles.
1. Low frequency of ceftazidime/avibactam resistance among Enterobacteriaceae isolates carrying blaKPC collected in U.S. hospitals from 2012 to 2015;Castanheira;Antimicrob Agents Chemother,2017
2. First report of ceftazidime/avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate;Humphries;Antimicrob Agents Chemother,2015
3. Clinical outcomes, drug toxicity, and emergence of ceftazidime/avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections;Shields;Clin Infect Dis,2016
4. Resistance to ceftazidime/avibactam is due to transposition of KPC in a porin-deficient strain of Klebsiella pneumoniae with increased efflux activity;Nelson;Antimicrob Agents Chemother,2017
5. Emergence of ceftazidime/avibactam resistance due to plasmid-borne blaKPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections;Shields;Antimicrob Agents Chemother,2017
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