An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists

Author:

Donskov Agnete Overgaard1ORCID,Mackie Sarah Louise23ORCID,Hauge Ellen Margrethe14,Toro-Gutiérrez Carlos Enrique5,Hansen Ib Tønder14,Hemmig Andrea Katharina6,Van der Maas Aatke7,Gheita Tamer8ORCID,Nielsen Berit Dalsgaard9,Douglas Karen M J10,Conway Richard11ORCID,Rezus Elena12,Dasgupta Bhaskar13,Monti Sara1415ORCID,Matteson Eric L16,Sattui Sebastian E17ORCID,Matza Mark18,Ocampo Vanessa19,Gromova Margarita20,Grainger Rebecca21ORCID,Bran Andrea22,Appenzeller Simone23,Goecke Annelise24,Colman Nelly25,Keen Helen I26ORCID,Kuwana Masataka27ORCID,Gupta Latika282930ORCID,Salim Babur31,Harifi Ghita32,Erraoui Mariam33,Ziade Nelly34ORCID,Al-Ani Nizar Abdulateef35,Ajibade Adeola2836,Knitza Johannes37ORCID,Frølund Line1,Yates Max3839,Pimentel-Quiroz Victor R4041ORCID,Lyrio Andre Marun42,Sandovici Maria43,Van der Geest Kornelis S M43ORCID,Helliwell Toby44,Brouwer Elisabeth43,Dejaco Christian4546ORCID,Keller Kresten Krarup14ORCID

Affiliation:

1. Department of Rheumatology, Aarhus University Hospital , Aarhus, Denmark

2. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds , Leeds, UK

3. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust , Leeds, UK

4. Department of Clinical Medicine, Aarhus University , Aarhus, Denmark

5. Reference center for Osteoporosis, Rheumatology & Dermatology , Cali, Colombia

6. Department of Rheumatology, University Hospital Basel , Basel, Switzerland

7. Rheumatology Department, St Maartenskliniek , Nijmegen, Netherlands

8. Rheumatology and Clinical Immunology, Cairo University , Cairo, Egypt

9. Department of Medicine, The Regional Hospital in Horsens , Horsens, Denmark

10. Department of Rheumatology, Dudley Group NHS FT , Dudley, UK

11. Department of Rheumatology, St. James’s Hospital , Dublin, Ireland

12. Department of Rheumatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy , Iasi, Romania

13. Department of Rheumatology, Southend University Hospital , Southend, UK

14. Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo , Pavia, Italy

15. Department of Internal Medicine and Therapeutics, Università di Pavia , Pavia, Italy

16. Division of Rheumatology, Mayo Clinic College of Medicine and Science , Rochester, USA

17. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA, USA

18. Rheumatology Unit, Massachusetts General Hospital , Boston, USA

19. Rheumatology Department-Scarborough Health Network and Kensington Eye Institute, University of Toronto—Center for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital , Toronto, Canada

20. Faculty Therapy, Pirogov National Russian Research Medical University , Moscow, Russian Federation

21. Department of Medicine, University of Otago Wellington , Wellington, New Zealand

22. Department of Medicine, Universidad Francisco Marroquín , Guatemala City, Guatemala

23. Department of Orthopedics, Rheumatology and Traumatology-School of Medical Science, University of Campinas , Campinas, Brazil

24. Rheumatology Section, Department of Medicine, University of Chile’s Clinical Hospital , Santiago, Chile

25. Universidad Nacional de Asunción, Hospital de Clinicas , Asunción, Paraguay

26. Medical School, UWA, Perth Australia, Rheumatology Department, Fiona Stanley Hospital , Perth, Australia

27. Department of Allergy and Rheumatology, Nippon Medical School , Tokyo, Japan

28. Department of Rheumatology, Royal Wolverhampton Hospital NHS Trust , Wolverhampton, UK

29. Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust , Birmingham, UK

30. Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester , Manchester, UK

31. Rheumatology, Fauji Foundation Hospital Rawalpindi , Rawalpindi, Pakistan

32. Rheumatology, Mediclinic Parkview Hospital, Dubai Health Authority , Dubai, United Arab Emirates

33. Faculty of Medicine and Pharmacy, Department of Rheumatology, Ibn Zohr University , Agadir, Morocco

34. Rheumatology, Saint-Joseph University , Beirut, Lebanon

35. Rheumatology Unit, Department of Medicine, University of Baghdad , Bagdhad, Iraq

36. Rheumatology Unit, Internal Medicine Department, Obafemi Awolowo University Teaching Hospitals Complex , Ile-Ife, Nigeria

37. German Centrum for Immune Therapy, Friedrich-Alexander-University Erlangen Nürnberg (FAU) and Universitätsklinikum Erlangen , Erlangen, Germany

38. Centre for Epidemiology, Norwich Medical School, University of East Anglia , Norwich, UK

39. Department of Rheumatology, Norfolk and Norwich University Hospital , Norwich, UK

40. Department of Rheumatology, Hospital Nacional Guillermo Almenara Irigoyen , Lima, Peru

41. Universidad Científica del Sur , Lima, Perú

42. Department of General Medicine/Rheumatology, Pontifical Catholic University of Campinas , Campinas, Brazil

43. Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen , Groningen, the Netherlands

44. School of Medicine, University of Staffordshire , Stafford, UK

45. Rheumatology, Medical University of Graz , Graz, Austria

46. Rheumatology, Hospital of Bruneck (SABES-ASAA) , Bruneck, Italy

Abstract

Abstract Objectives To explore current management practices for PMR by general practitioners (GPs) and rheumatologists including implications for clinical trial recruitment. Methods An English language questionnaire was constructed by a working group of rheumatologists and GPs from six countries. The questionnaire focused on: 1: Respondent characteristics; 2: Referral practices; 3: Treatment with glucocorticoids; 4: Diagnostics; 5: Comorbidities; and 6: Barriers to research. The questionnaire was distributed to rheumatologists and GPs worldwide via members of the International PMR/Giant Cell Arteritis Study Group. Results In total, 394 GPs and 937 rheumatologists responded to the survey. GPs referred a median of 25% of their suspected PMR patients for diagnosis and 50% of these were returned to their GP for management. In general, 39% of rheumatologists evaluated patients with suspected PMR >2 weeks after referral, and a median of 50% of patients had started prednisolone before rheumatologist evaluation. Direct comparison of initial treatment showed that the percentage prescribing >25 mg prednisolone daily for patients was 30% for GPs and 12% for rheumatologists. Diagnostic imaging was rarely used. More than half (56%) of rheumatologists experienced difficulties recruiting people with PMR to clinical trials. Conclusion This large international survey indicates that a large proportion of people with PMR are not referred for diagnosis, and that the proportion of treatment-naive patients declined with increasing time from referral to assessment. Strategies are needed to change referral and management of people with PMR, to improve clinical practice and facilitate recruitment to clinical trials.

Funder

AbbVie

Swiss Foundation for Research on Muscle Diseases

Aarhus University Hospital and Central Denmark Region

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

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