Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study
Author:
Dal Santo Tiffany12, Rice Danielle B34, Carrier Marie-Eve1, Virgili-Gervais Gabrielle1, Levis Brooke1ORCID, Kwakkenbos Linda567, Golberg Meira1, Bartlett Susan J89ORCID, Gietzen Amy10, Gottesman Karen11, Guillot Geneviève12, Hudson Marie18, Hummers Laura K13, Malcarne Vanessa L1415, Mayes Maureen D16, Mouthon Luc1718, Richard Michelle1920, Sauvé Maureen1921, Wojeck Robyn K22, Geoffroy Marie-Claude223, Benedetti Andrea892425ORCID, Thombs Brett D128252627ORCID, , Fortuné Catherine, Adams Claire E, El-Baalbaki Ghassan, Fligelstone Kim, Frech Tracy, Harel Daphna, Henry Richard S, Hinchcliff Monique, Johnson Sindhu R, Larche Maggie, Leite Catarina, Nguyen Christelle, Nielsen Karen, Pope Janet, Rannou François, Rodriguez-Reyna Tatiana Sofia, Schouffoer Anne A, Suarez-Almazor Maria E, Agard Christian, Alric Laurent, André Marc, Beaslay Floryan, Bernstein Elana J, Berthier Sabine, Bissonnette Lyne, Blaise Sophie, Bories Eva, Bruns Alessandra, Cacciatore Carlotta, Carreira Patricia, Casadevall Marion, Chaigne Benjamin, Chung Lorinda, Crichi Benjamin, Deltombe Thylbert, Denton Christopher, Desroche Tannvir, Domsic Robyn, Dunne James V, Dunogue Bertrand, Fare Regina, Farge-Bancel Dominique, Fortin Paul R, Gauzère Loraine, Gerber Anne, Gordon Jessica, Granel-Rey Brigitte, Guffroy Aurélien, Gyger Geneviève, Hachulla Eric, Hoa Sabrina, Hughes Michael, Ikic Alena, Jones Niall, Kafaja Suzanne, Khalidi Nader, Lakin Kimberly, Lambert Marc, Launay David, Lee Yvonne C, Legendre Paul, Maillard Hélène, Maltez Nancy, Manning Joanne, Marie Isabelle, Lopez Maria Martin, Martin Thierry, Masetto Ariel, Maurier François, Mekinian Arsène, Díaz Sheila Melchor, Mourguet Morgane, Nikpour Mandana, Olagne Louis, Poindron Vincent, Proudman Susanna, Pugnet Grégory, Raffray Loïc, Régent Alexis, Renou Frederic, Rivière Sébastien, Robinson David, Almazar Esther Rodríguez, Roux Sophie, Smets Perrine, Sobanski Vincent, Spiera Robert, Steen Virginia, Sutton Evelyn, Thorne Carter, Vagner Damien, Varga John, Wilcox Pearce, Ayala Mara Cañedo, Cook Vanessa, Hu Sophie, Nassar Elsa-Lynn, Neyer Marieke Alexandra, Provencher Sabrina
Affiliation:
1. Lady Davis Institute for Medical Research, Jewish General Hospital , Montreal, QC, Canada 2. Department of Psychiatry, McGill University , Montreal, QC, Canada 3. Department of Psychology, St Joseph’s Healthcare Hamilton , Hamilton, ON, Canada 4. Department of Psychiatry and Behavioural Neurosciences, McMaster University , Hamilton, ON, Canada 5. Department of Clinical Psychology, Behavioural Science Institute, Radboud University , Nijmegen, The Netherlands 6. Department of IQ Healthcare, Radboud University Medical Center , Nijmegen, The Netherlands 7. Department of Psychiatry, Radboud University Medical Center , Nijmegen, The Netherlands 8. Department of Medicine, McGill University , Montreal, QC, Canada 9. Research Institute of the McGill University Health Centre , Montreal, QC, Canada 10. National Scleroderma Foundation, Tri-State Chapter , Buffalo, NY, USA 11. National Scleroderma Foundation , Los Angeles, CA, USA 12. Sclérodermie Québec , Longueuil, QC, Canada 13. Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology , Baltimore, MD, USA 14. Department of Psychology, San Diego State University , San Diego, CA, USA 15. San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California , San Diego, CA, USA 16. Department of Internal Medicine, Division of Rheumatology, University of Texas McGovern School of Medicine , Houston, TX, USA 17. Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin , Paris, France 18. Assistance Publique Hôpitaux de Paris-Centre, Hôpital Cochin, Université Paris Cité , Paris, France 19. Scleroderma Canada , Hamilton, ON, Canada 20. Scleroderma Atlantic , Halifax, NS, Canada 21. Scleroderma Society of Ontario , Hamilton, ON, Canada 22. College of Nursing, University of Rhode Island , Kingston, RI, USA 23. Douglas Research Centre, McGill Group for Suicide Studies , Montreal, QC, Canada 24. Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre , Montreal, QC, Canada 25. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University , Montreal, QC, Canada 26. Biomedical Ethics Unit, McGill University , Montreal, QC, Canada 27. Department of Psychology, McGill University , Montreal, QC, Canada
Abstract
Abstract
Objectives
To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors.
Methods
Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.
Results
Among 2385 participants, the mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in the multivariable analysis included older age (−0.74 points per SD years, 95% CI −0.78 to −1.08), female sex (−1.35, −2.37 to −0.34), fewer years of education (−0.41 points per SD in years, −0.75 to −0.07), being single, divorced, or widowed (−0.76, −1.48 to −0.03), smoking (−3.14, −4.42 to −1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45–1.14), BMI (−1.41 points per SD, −1.75 to −1.07), diffuse subtype (−1.43, −2.23 to −0.62), gastrointestinal involvement (−2.58, −3.53 to −1.62), digital ulcers (−1.96, −2.94 to −0.98), moderate (−1.94, −2.94 to −0.93) and severe (−1.76, −3.24 to −0.28) small joint contractures, moderate (−2.10, −3.44 to −0.76) and severe (−2.54, −4.64 to −0.44) large joint contractures, interstitial lung disease (−1.52, −2.27 to −0.77), pulmonary arterial hypertension (−3.72, −4.91 to −2.52), rheumatoid arthritis (−2.10, −3.64 to −0.56) and idiopathic inflammatory myositis (−2.10, −3.63 to −0.56).
Conclusion
Physical function is impaired for many individuals with SSc and is associated with multiple disease factors.
Funder
Scleroderma Patient-centered Intervention Network Canadian Institutes of Health Research Lady Davis Institute for Medical Research of the Jewish General Hospital Jewish General Hospital Foundation McGill University
Publisher
Oxford University Press (OUP)
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