1. Department of Clinical Genetics, Guy’s and St Thomas’ NHS Foundation Trust, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK
2. Department of Clinical Genetics, Birmingham Women’s and Children’s Hospital, Mindelsohn Way, Birmingham B15 2TG, UK and University of Birmingham and Birmingham Health Partners, Edgbaston, Birmingham B152TT, UK
3. Department of Medical and Molecular Genetics, Faculty of Life Sciences, King’s College London, Strand London WC2R 2LS, UK