Can Precision Oncology Benefit Patients With Cancers of Unknown Primary?

Author:

Rassy Elie12ORCID,Andre Fabrice13

Affiliation:

1. Gustave Roussy, Départements de Médecine Oncologique, F-94805 , Villejuif , France

2. CESP, INSERM U1018, Université Paris-Saclay , Villejuif , France

3. Gustave Roussy, INSERM U981, Université Paris-Saclay , Villejuif , France

Abstract

This editorial calls for a strategic shift in our approach to cancers of unknown primary (CUP), one that generates a comprehensive multidimensional portrait of cancer in patients with CUP, to model the biology at the individual level and identify the right therapeutic target accordingly. The framework of this approach is based on the integration of basic biology, biotechnologies, data sciences, clinical research, and social sciences.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference14 articles.

1. Hallmarks of cancer: new dimensions;Hanahan,2022

2. Commentary on “tumor heterogeneity and the biology of cancer invasion and metastasis.”;Fidler,2016

3. Not only tumor but also therapy heterogeneity;Garattini;Ann Oncol,2018

4. Precision oncology: who, how, what, when, and when not;Schwartzberg,2017

5. Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group;Mosele,2020

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