1. Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedical Research Building (Second Floor) , Newcastle upon Tyne NE1 7RU , UK
2. Department of Mathematical Sciences , Mathematical Sciences & Computer Science Building, , Upper Mountjoy Campus, Stockton Road, Durham, DH1 3LE , UK
3. Durham University , Mathematical Sciences & Computer Science Building, , Upper Mountjoy Campus, Stockton Road, Durham, DH1 3LE , UK