Affiliation:
1. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, New Campus, Nanbaixiang, Ouhai District, Wenzhou 325000, China
Abstract
OBJECTIVE: To conduct a systematic review of the literature and assess the effect of PM2.5 (particulate matter with diameter <2.5 μm) exposure on lung function in adults with asthma.METHODS: We searched all literature published between 1 January 2010 and 26 March
2019 in the EMBASE, PubMed, Cochrane Central Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang and Chinese Biomedical Literature (CBM) databases. The studies were assessed for analytic methods, risk of bias and results of statistical analysis.RESULTS: The selected
studies all had a low or moderate risk of bias. Overall, PM2.5 exposure was positively associated with a decrease in forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC) in adults with asthma (standardised mean difference 0.20, 95% CI 0.02–0.38; P =
0.03).CONCLUSION: We observed a negative correlation between PM2.5 exposure and FEV1/FVC in patients with asthma. Our meta-analysis provides evidence suggesting that PM2.5 is a risk factor for acute asthma exacerbation in adults.
Publisher
International Union Against Tuberculosis and Lung Disease
Subject
Infectious Diseases,Pulmonary and Respiratory Medicine
Cited by
9 articles.
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