Affiliation:
1. Center for Science and Technology of Advanced Materials
2. Synchrotron Light Research Institute
3. Polytechnic Institute of Nuclear Technology
Abstract
The fibrillation mechanism of insulin in acid solution has been studied by small angle X-ray scattering (SAXS). It was observed that insulin monomer unfolded in both conditions. Furthermore, in zinc free solution, insulin tend to aggregate on heating start in the first 5 min. The fibrillation through aggregation process continues until 30 min on heating. The similar phenomenon occurs in the presence of zinc ions. The SAXS data suggest that the presence of zinc ions prevent the long cylindrical fibril at the beginning of heating. However, after 20 min heating, the large cylindrical fibril of insulin formed in both conditions.
Publisher
Trans Tech Publications, Ltd.
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
3 articles.
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