Free Radical Scavenging Properties and Anti-Fatigue Activities of Angelica sinensis Polysaccharides

Abstract

In this study, radical scavenging properties and anti-fatigue activities ofAngelica sinensispolysaccharides (ASP) were evaluated in vitro and in vivo, respectively. Forced swimming test of mice were carried out after 30 days of ASP administration (60, 120, 240 mg/kg·d), and the blood glucose, blood lactate, hemoglobin, liver glycogen and muscle glycogen were determined. The in vitro study showed that ASP had antioxidant activities, which exhibited scavenging effects on 2,2-Diphenyl-1-picrylhydrazyl (DPPH), hydroxyl and superoxide anions radicals. The in vitro study showed that ASP had anti-fatigue activities, which could extend the exhaustive swimming time, increase levels of blood glucose, hemoglobin, liver glycogen and muscle glycogen activities, and decrease blood lactate levels of mice.