Study on Synthesis of a Series of Amino Functional Cholesterylated Hepatic Targeting Liposome Ligands

Abstract

A series of hepatic amino functional cholesterylated hepatic targeting liposome ligands L1-L6 were synthesized. Cholesterol as starting material, after esterification with p-toluenesulfonyl chloride to get cholesterol tosylate, then etherification with oligo ethylene ethanol (n=1-3) to get amino functional cholesterylated compounds T1-T3, T1-T3 were elongated by reaction with protected diethylene glycol and deprotected in acid condition to get T4-T6 . L1-L6 were mesylated and replaced by azido group, then hydrogenanted by hydrogen to get L1-L6.The target compounds affords cholesterylated hepatic targeting liposome ligands.