Affiliation:
1. Amirkabir University of Technology (Tehran Polytechnic)
2. Amirkabir University of Technology (Iran Poly Technique)
3. Tehran University of Medical Sciences
Abstract
This study has focused on mesoporous silica nanoparticles as a drug delivery system of insulin, which was synthesized via a hydrothermal process. The morphology and composition of the silica nanoparticles were characterized by different analytical techniques such as Scanning Electron Microscope (SEM), X-Ray Diffraction Analysis (XRD), Fourier Transform Infrared spectroscopy (FTIR) and BrunauerEmmettTeller (BET). The percentage of drug loading and the in vitro drug release properties of the mesoporous silica nanoparticles in gastrointestinal tract were investigated in simulated gastrointestinal conditions by ultraviolet-visible spectroscopy. The results showed the amorphous structure of SBA-15 in mesoporous silica particles has a narrow pore size distribution. Also, particles shape was nearly wheat-like with almost homogeneous size distribution. Furthermore, it was revealed that the mesoporous silica nanoparticles have a high insulin loading and release capacity. These prominent behaviors make mesoporous silica nanoparticles promising material as a drug carrier for insulin delivery.
Publisher
Trans Tech Publications, Ltd.
Reference13 articles.
1. John G. Webster, Encyclopedia of Medical Devices and Instrumentation, 2006, pp.438-439.
2. H. Qianjun, Y. Gao, L. Zhang, Zh. Zhang, F. Gao, X. Ji, Y. Li, J. Shi, A pH mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials. 32 (2011) 7711-7720.
3. R.I. Mabato, A.S. Narang, L. Thoma, D. D. Miller, Emerging trends in oral delivery of peptide and protein drugs, 2003, pp.164-167.
4. Jessy Shaji, V Patole, Protein and peptide drug delivery: Oral approaches, Indian J. Pharm. Sci. 70 (2008) 269-277.
5. I.A. Rahman, P. Vejayakumaran, C.S. Sipaut, J. Ismail, M. Abu Bakar, R. Adnan, C. K, Chee, A pH mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance, Biomaterials. 294 (2007) 102 – 110.
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献