Recent Advance in Synthesis and Application of Inorganic Glyconanoparticles as Bio-Therapeutics and Diagnostics Agents

Abstract

Carbohydrates are attractive molecules for drug discovery because sugars are involved in many intricate human diseases including cancer and infectious diseases. Potential therapeutic and diagnostic benefits of sugar-based drugs, however, are offset by the poor pharmacologic properties of these molecules that include speedy serum clearance, poor cellular uptake, and the relatively high concentrations required for efficacy. To address these issues, carbohydrates are functionalized with nanocarrier as similar to peptides, proteins and DNA. Considering the vast relevance of Inorganic nanoparticles as promising candidates for electronic, optical, magnetic and biomedical applications, several metals linked glyconanoparticles (GNPs) are synthesized and applied for biomedical application. This article will elaborately discuss about the progress in the development of metallic GNPs for various biological applications as drug candidates and detection agents.