Functions of Yes-association protein (YAP) in cancer progression and anticancer therapy resistance-Reference-Cited by-同舟云学术

Functions of Yes-association protein (YAP) in cancer progression and anticancer therapy resistance

Published:2022-03 Issue:1 Volume:8 Page:1-18
ISSN:2096-5958
Container-title:Brain Science Advances
language:en
Short-container-title:Brain Science Advances

Author:

Zhang Yu¹²³,Wang Xiang¹⁴³,Zhou Xiuping¹²

Affiliation:

1. Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, Jiangsu, China

2. Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China

3. These authors contributed equally to this work.

4. The Graduate School, Xuzhou Medical University, Xuzhou 221002, Jiangsu, China

Abstract

The Hippo pathway, a highly conserved kinase cascade, regulates cell proliferation, apoptosis, organ size, and tissue homeostasis. Dysregulation of this pathway reportedly plays an important role in the progression of various human cancers. Yes-association protein (YAP), the Hippo pathway’s core effector, is considered a marker for cancer therapy and patient prognosis. In addition, studies have indicated that YAP is involved in promoting anticancer drug resistance. This review summarizes current knowledge on YAP’s role in cancer progression, anticancer drug resistance, and advances in the development of YAP-targeting drugs. A thorough understanding of the complex interactions among molecular, cellular, and environmental factors concerning YAP function in cancer progression may provide new insight into the underlying mechanism of anticancer drug resistance. It might lead to improved prognosis through novel combined therapies.

Publisher

Tsinghua University Press

Subject

Microbiology (medical),Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.26599/BSA.2022.9050008

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