Clinical evaluation of intravenous nitroglycerin for neurosurgery

Author:

Chestnut Julian S.,Albin Maurice S.,Gonzalez-Abola Evelyn,Newfield Philippa,Maroon Joseph C.

Abstract

✓ Moment-to-moment control of blood pressure is important in the management of the neurosurgical patient. The ideal agent to control blood pressure or induce hypotension should be non-toxic, maintain cerebrovascular autoregulation, and not alter cardiac output or change intracranial pressure. Intravenous nitroglycerin has been used to control blood pressure in 54 neurosurgical cases. This agent produces a rapid, controllable, but not precipitous fall in blood pressure without rebound, is non-toxic, may not alter cerebrovascular autoregulation, and does not raise intracranial pressure. Our clinical experience with intravenous nitroglycerin indicates that it has an important role as a hypotensive agent for the neurosurgical patient.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

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