Author:
Austin-Seymour Mary,Munzenrider John,Goitein Michael,Verhey Lynn,Urie Marcia,Gentry Richard,Birnbaum Steven,Ruotolo Donna,McManus Patricia,Skates Steven,Ojemann Robert G.,Rosenberg Andrew,Schiller Alan,Koehler Andreas,Suit Herman D.
Abstract
✓ Sixty-eight patients with chordoma or low-grade chondrosarcoma at the base of the skull received fractionated high-dose postoperative radiation delivered with a 160-MeV proton beam. Protons have favorable physical characteristics which allow the delivery of high doses of radiation to these critically located tumors. The methods employed for these treatments are described. These patients have been followed for at least 17 months and for a median of 34 months. The median tumor dose was 69 CGE (cobalt Gy equivalent): CGE is the dose in proton Gy multiplied by 1.1, which is the relative biological effectiveness for protons compared to cobalt-60. The daily dose was 1.8 to 2.1 CGE. For this group the 5-year actuarial local control rate is 82% and disease-free survival rate is 76%. The incidence of treatment-related morbidity has been acceptable.
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Cited by
285 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献