Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case-Reference-Cited by-同舟云学术

Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case

Published:2022-03-21 Issue:12 Volume:3 Page:
ISSN:2694-1902
Container-title:Journal of Neurosurgery: Case Lessons
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Author:

Simeone Claire A.¹²,Andrews John P.³,Johnson Shawn P.¹,Casalia Mariana³,Kochanski Ryan³,Chang Edward F.³,Cameron Dianne²,Dennison Sophie⁴,Inglis Ben⁵,Scott Gregory²,Kruse-Elliott Kris⁶,Okonski F. Fabian⁷,Calvo Eric²,Goulet Kelly²,Robles Dawn²,Griffin-Stence Ashley²,Kuiper Erin²,Krasovec Laura⁸,Field Cara L.⁹,Hoard Vanessa F.¹⁰,Baraban Scott C.³

Affiliation:

1. Sea Change Health, Kentfield, California

2. Six Flags Discovery Kingdom, Vallejo, California

3. Department of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California

4. TeleVet Imaging Solutions, Oakton, Virginia

5. Henry H. Wheeler, Jr. Brain Imaging Center, University of California, Berkeley, Berkeley, California

6. Sage Veterinary Centers, Redwood City, California

7. Department of Anesthesiology, Perioperative and Pain Medicine, Lucile Packard Children’s Hospital at Stanford, Stanford School of Medicine, Stanford, California

8. BrainLab, Westchester, Illinois

9. The Marine Mammal Center, Sausalito, California; and

10. Pacific Marine Mammal Center, Laguna Beach, California

Abstract

BACKGROUND Domoic acid (DA) is a naturally occurring neurotoxin harmful to marine animals and humans. California sea lions exposed to DA in prey during algal blooms along the Pacific coast exhibit significant neurological symptoms, including epilepsy with hippocampal atrophy. OBSERVATIONS Here the authors describe a xenotransplantation procedure to deliver interneuron progenitor cells into the damaged hippocampus of an epileptic sea lion with suspected DA toxicosis. The sea lion has had no evidence of seizures after the procedure, and clinical measures of well-being, including weight and feeding habits, have stabilized. LESSONS These preliminary results suggest xenotransplantation has improved the quality of life for this animal and holds tremendous therapeutic promise.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

Management Science and Operations Research,Mechanical Engineering,Energy Engineering and Power Technology

Link

https://thejns.org/downloadpdf/journals/j-neurosurg-case-lessons/3/12/article-CASE21417.xml

Reference19 articles.

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2. Domoic acid toxicity in Californian sea lions (Zalophus californianus): clinical signs, treatment and survival;Gulland FM,2002

3. Novel symptomatology and changing epidemiology of domoic acid toxicosis in California sea lions (Zalophus californianus): an increasing risk to marine mammal health;Goldstein T,2008

4. Domoic acid epileptic disease;Ramsdell JS,2014

5. Clinical signs and mortality of non-released stranded California sea lions housed in display facilities: the suspected role of prior exposure to algal toxins;Simeone C,2019

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3. Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment;Frontiers in Neuroscience;2023-04-14

4. Uncertainty and excitement surround one company’s cell therapy for epilepsy;Spectrum;2023

5. Clinical Observations Associated with Phenobarbital Serum Monitoring to Manage Epilepsy in a California Sea Lion with Domoic Acid Toxicosis;Oceans;2022-07-27