INFLAMMAGING IN MUSCLE: THE MISSING LINK BETWEEN SARCOPENIA AND IDIOPATHIC INFLAMMATORY MYOPATHIES

Abstract

Ageing is associated with a progressive decline in muscle mass and quality. Inflammaging, chronic low-grade inflammation is a major causative as well as maintenance factor in age-related disorders. Idiopathic inflammatory myopathies or myositis also exhibit a chronic stage of inflammation caused by various immune and non-immune-mediated processes. This review draws parallels between the mechanisms of inflammaging, sarcopenia, and myositis, and their possible interconnection. We searched literature on information about myositis, sarcopenia, ageing, inflammaging, and senescence to draw parallels between the mechanisms linking myositis, sarcopenia, and inflammaging. Further, we discuss the evidence base to support that the process of senescence is hastened in an inflamed muscle [1].