BACKGROUND
Argireline, a topical, short-acting neurotoxin, has recently gained popularity for its anti-wrinkle effects and has emerged as a more accessible alternative to Botulinum neurotoxin (BoNT).
OBJECTIVE
This study evaluates public interest of Argireline in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine.
METHODS
Longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, was analyzed for Argireline-related terms. Internet search trends for “Botox” during this period were compared to “Argireline” and state-specific interest was identified.
RESULTS
Terms “Argireline” and “Botox in a bottle” both had significant increases in search volume in 2022. Although its search volume is drastically increasing, “Argireline” was significantly less searched than “Botox,” which had a stable, up-trending search volume over the past decade.
CONCLUSIONS
The increasing interest in Argireline may be due to its cost efficacy and use as a BoNT alternative. Argireline’s affordability, over-the-counter availability, and ease of self-application suggest its potential to enhance accessibility to cosmetic dermatologic care.