Clinicopathologic Characteristics and Chemotherapy Response of Classic Hodgkin Lymphoma: A Study in Tertiary Teaching Hospital

Abstract

Background and Objective: Hodgkin Lymphoma (HL) is known as a malignancy of the lymphatic system and 90% of the HL is Classic Hodgkin Lymphoma (CHL). Prognostic factors that identify the patient's response to therapy are useful for optimizing the therapy. This study aims to assess the clinicopathological characteristics and chemotherapy response associated with CHL patients. Materials and Methods: This is a retrospective study of 40 patients diagnosed as CHL and treated with ABVD chemotherapy at Hasan Sadikin General Hospital/Padjadjaran University, Bandung, Indonesia during the period of January 2014 to December 2019. The clinicopathological characteristics data consisting of age, sex, histopathology subtype, tumor location and clinical stage were assessed. Their responses to chemotherapy were also analyzed. Result and Discussion: A total of 40 patient data were included in this study, 21 CHL patients responded to ABVD chemotherapy (52.5%) while 19 patients not responded (47.5%). There were no significant association between age, sex, histopathological subtype, tumour location and clinical stage with chemotherapy response. Conclusion: In this study, 47.5% of CHL patients did not respond to ABVD chemotherapy. The response of ABVD chemotherapy was not associated with age, sex, histopathological subtype, tumor location or clinical stage. Keywords: Classic Hodgkin Lymphoma, chemotherapy response, clinicopathological characteristics.