EXPLORING POTENTIAL OF INDOLE DERIVATIVES: A BRIEF REVIEW

Abstract

In general, heterocyclic compounds are rich in pharmacologically active chemicals. Among them are anti-inflammatory, antitubercular, anti-HIV, antimalarial, antidiabetic, anticonvulsants, analgesics, antihypertensive, antifungal, anticancer, antidepressant, antioxidant, and antimicrobial compounds. Due to their wide range of activity in the fields of drug design, Heterocycles occupy a salient place in chemistry. One of the most hopeful heterocycles found in natural and synthetic sources is the indole scaffold which possesses variety of biological activity, including anti-inflammatory, antitubercular, anti-HIV, antimalarial, antidiabetic, anticonvulsants, analgesics, antihypertensive, antifungal, anticancer, antidepressant, antioxidant, and antimicrobial, etc. This review aimed to highlight the synthetic perspective on the development of indole-based analogs. This study aimed to offer clear information on the current development of indoles as anticonvulsant, anticancer, and anti-inflammatory agents.