Author:
DINNIMATH BASAVARAJ M.,GOWDA POOJA,NAIK ANWESH
Abstract
Schiff bases are well-known synthetic compounds which are known to be used as drug molecules for various pharmacological and therapeutic applications. These compounds were prepared synthetically in simple steps and used against various diseases as antimicrobial agents, anti-HIV agents, antitumour agents, industrial applications like enzymatic reactions, catalytic activity. However, considering the various challenges posed by different microorganisms to the conventional Schiff bases, medicinal chemists have initiated the novel approach by synthesizing the new lead compounds for different pharmacological activities containing complexes of Schiff bases with different metals as these are new compounds and potent molecules due to duo combination with metals. This combination has gained prominence now a days against those diseases for which Schiff bases are becoming ineffective, such as cancer due to resistance and irrational usage. Hence, this review is an attempt to throw some light on the recent developments in the world of new drug molecules comprising of Schiff bases complexes with different metals like Copper (Cu), Palladium (Pd), Aluminium (Al), gold (Au), Silver (Ag) etc.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmaceutical Science,Pharmacology
Reference43 articles.
1. Chaturvedi D, Kamboj M. Role of Schiff base in drug discovery research. Chem Sci J. 2016;7(2):1-2. doi: 10.4172/2150-3494.1000e114.
2. Zhukova OV, Ryabov SA, Zaitsev SD, Kuznetsova OV, Gavrilova DM, Archipova EV. Water-soluble polymeric ionic 5-fluorouracil complex based on methacrylic acid copolymers. Int J App Pharm. 2019 May;11(4):214-9. doi: 10.22159/ijap.2019v11i4.32919.
3. Jurca T. Spectroscopic analyses-developments and application. Intech. 2017;7:123.
4. Parkali P, Dinnimath BM. Scope of azetidinone hybrids for diverse pharmacological activities: a review. IJPSR. 2021.
5. Dinnimath BM, Hipparagi SM, Munishamagowda. Synthesis of chloro, fluoro and phenyl substituted azetidine-2-one deriva-tives by microwave method and screening for antimicrobial activities. Int J Pharm Technol. 2011;3(4):3792-801.
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