EVALUATION OF ANTI ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF GYMNEMA SYLVESTRE ON ALBINO WISTAR RATS

Abstract

Objective: The present research is designed to evaluate the anti-ulcer activity of HAGS (Hydroalcoholic extract of Gymnema sylvestre) in NSAIDs and pylorus ligation-induced rat models. Methods: The antiulcer activity of the hydroalcoholic extracts of Gymnema sylvestre (100 and 200 mg/kg, p. o.) was evaluated in ethanol, indomethacin, pylorus ligation and acetic acid-induced ulcer models in rats. Parameters such as mean ulcer indices and percentage ulcer inhibition were assessed in ethanol, indomethacin and acetic acid-induced ulcer models, while the gastric volume, pH, and titratable acidity were evaluated in the pylorus ligation ulcer model. Results: Hydroalcoholic extract of Gymnema sylvestre (100 mg/kg) and (200 mg/kg) could significantly (P<0.001) reduce the ulcer index, ulcerated area and total acidity compared to standard drug and thereby significantly (P<0.001) increase percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. A significant increase was observed in pH, NP-SH, GSH, enzymic antioxidants and protein with a significant decrease in volume of gastric juice, free and total acidity, acid output and LPO levels activities in 100 mg/kg and 200 mg/kg of HAGS treated rats compared to disease control rats. The effect of extracts was dose-dependent and results were comparable to that of the standard drug Cimetidine. Conclusion: It is concluded that the Hydroalcoholic extract of Gymnema sylvestre shows a significant effect on NSAIDs and Pylorus ligation-induced rat models. It shows a significant reduction in the lesion index.