DESIGN AND INVITRO CHARACTERIZATION OF METFORMIN LOADED RESEALED ERYTHROCYTES
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Published:2017-04-01
Issue:4
Volume:10
Page:231
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ISSN:2455-3891
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Container-title:Asian Journal of Pharmaceutical and Clinical Research
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language:
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Short-container-title:Asian J Pharm Clin Res
Author:
Viswanad Vidya,S Aiswarya,S Parvathy,Tp Aneesh
Abstract
Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The objective of the present study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation.Methods: The study retards the release of metformin by encapsulating in carier erythrocyte. Endocytosis is the method used for the encapsulation of the drug metormin.Results: The optimized formulation shows 98.34% of drug release within 12 days. From the invitro release data zero order kinetic graph shows the best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive.Conclusion: The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin.Keywords: Resealed erythrocytes, cross linking, cell recovery, endocytosis, slow release depot formulation
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Cited by
2 articles.
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