Author:
MAHERDA LAKSHITA,JAIN KALPANA,AGARWAL PULAK,BHARGAWA POONAM
Abstract
Objective: The objective of this study was to evaluate the association of serum leptin levels with presence and severity of age-related macular degeneration (AMD).
Methods: A hospital-based case–control study conducted on 84 patients (42 cases and 42 controls) of either sex complaining of diminution of vision aged 40 years and above between August 2019 and 2021.
Results: Mean serum leptin level in cases was 1.55±0.99 ng/mL and control was 2.11±0.88 ng/mL (p<0.008). The serum leptin level was negatively correlated with early (1.06±0.99 ng/mL), intermediate (0.50±0.08 ng/mL), and dry age-related macular degeneration (ARMD) (0.29±0.12 ng/mL). However, we found higher serum leptin levels in exudative ARMD (2.58±0.99 ng/mL). Maximum number of cases were of exudative AMD (42.86%) followed by early AMD (33.34%) and intermediate and dry AMD (11.91% each).
Conclusion: We found a decrease in serum leptin levels as disease severity increases from the early AMD to intermediate AMD and Dry AMD. However, the levels of serum leptin levels were higher in patients with exudative AMD. This may be due to some pathological process that is different in dry and exudative AMD. This can form the basis for further research in future.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference19 articles.
1. Yanoff M, Jay S. Duker book of ophthalmology. In: 29-Age Related Macular Degeneration. 5th ed., Ch. 6. Netherlands: Elsevier; 2019.
2. Seshasai S, Liao J, Toh QC, Cheng CY, Cheung GC, Sethi S, et al. Serum leptin and age-related macular degeneration. Invest Ophthalmol Vis Sci 2015;56:1880-6. doi: 10.1167/iovs.14-15933, PMID 25711634
3. Chew EY, Clemons TE, Agrón E, Sperduto RD, Sangiovanni JP, Davis MD, et al. Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36. JAMA Ophthalmol 2014;132:272-7. doi: 10.1001/jamaophthalmol.2013.6636, PMID 24385141
4. Dornbush S, Aeddula NR. Physiology, leptin. In: StatPearls. Treasure Island, FL: StatPearls; 2022.
5. Jéquier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci 2002;967:379-88. doi: 10.1111/j.1749-6632.2002.tb04293.x, PMID 12079865