Author:
SHARMA ASHISH,SHARMA ARNAV
Abstract
Objective: This study was performed to see the effects of aqueous extract of purified Curcuma longa (CL) on motor performance of albino mice using rota test.
Methods: CL at 50mg/kg body weight (b.w.) (CL50), CL at 100 mg/kg b.w. (CL100), and CL at 200 mg/kg b.w. (CL200) with negative and positive controls were used. The experimental results were represented as mean±2 standard deviation, p was set at < 0.05. Statistical differences between the test drug and control groups as well as within the test drug groups were calculated using Mann–Whitney U-test.
Results: As compared to CL200, DW (distilled water 10 ml/kg p.o.) group fall off time was significantly less (p=0.004). Diazepam (5 mg/kg i.p.) group stayed for lesser time on the rotating rod than CL50, CL100, and CL200 groups (p=0.004). Fall off time in CL100 group was significantly lesser than CL 200 group (p=0.019).
Conclusion: This study showed that CL possesses motor performance increasing effects at 200 mg.
Publisher
Innovare Academic Sciences Pvt Ltd
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference25 articles.
1. Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett 1995;94:79-83.
2. Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol 1995;47:59-67.
3. Balakrishnan KV. Postharvest technology and processing of turmeric. In: Ravindran PN, Babu KN, Sivaraman K, editors. Turmeric: The Genus Curcuma. 1st ed. Boca Raton, FL: CRC Press; 2007. p. 193-256.
4. Goud VK, Polasa K, Krishnaswamy K. Effect of turmeric on xenobiotic metabolising enzymes. Plant Foods Hum Nutr 1993;44:87-92.
5. Ohshiro M, Kuroyanag M, Keno A. Structures of sesquiterpenes from Curcuma longa. Phytochemistry 1990;29:2201-5.