Affiliation:
1. A.S. MacDonald and R.M. Maizels are at the Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
Abstract
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
132 articles.
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