Affiliation:
1. From The Department of Medicine and Bacteriology, Duke University School of Medicine, Durham
Abstract
The kidney of guinea pigs infected with the H37Rv and BCG strains of M. tuberculosis showed a diminution in succinic dehydrogenase activity when measured by the tetrazolium technique. This effect was also seen in the liver and spleen of animals infected with the BCG strain. Sensitized animals showed similar results when given tuberculin in sublethal doses. The succinic oxidase was also low in the kidneys of animals infected with the H37Rv strain.
The depressed enzyme activity of the tissues of infected animals could be restored to normal by addition of normal tissue extract or dialysate. This suggests that the alteration in tissue metabolism observed in tuberculosis may depend upon the loss of some as yet unidentified factor important for succinic dehydrogenase activity.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
21 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Thiamin and riboflavin status with related enzyme activities in pulmonary tuberculosis with diabetes mellitus in Shandong province of China;ASIA PAC J CLIN NUTR;2022
2. Experimental Animal Models of Tuberculosis;Handbook of Tuberculosis;2017-09-18
3. DIET AND EXPERIMENTAL TUBERCULOSIS IN THE GUINEA-PIG;Acta Pathologica Microbiologica Scandinavica;2009-08-18
4. Succinic Dehydrogenase Activity in Tuberculous Animals;Ciba Foundation Symposium - Experimental Tuberculosis: Bacillus and Host (with an Addendum on Leprosy);2008-05-30
5. The Mechanism Involved in Acquired Immunity to Tuberculosis;Ciba Foundation Symposium - Experimental Tuberculosis: Bacillus and Host (with an Addendum on Leprosy);2008-05-30