Affiliation:
1. From the Pathological Laboratory of the University of Wisconsin, Madison, Wisconsin.
Abstract
1. Two important methods for the study of malarial pigment are described.
(a) A method for obtaining a solution of malarial pigment from fixed tissues without the removal of a trace of hemoglobin from the red blood corpuscles.
(b) A method for obtaining an iron reaction in malarial pigment.
2. By comparing the bleach reactions and solubility of melanins and malarial pigment, the dissimilarity of the two classes of pigments has been demonstrated.
3. The spectroscopic examination of a solution of malarial pigment proves conclusively that the pigment is hematin.
4. It is suggested that the action of a proteolytic enzyme of the malarial parasite upon the hemoglobin of the red blood corpuscle is the most probable mode of elaboration of malarial pigment.
5. The difficulty with which the human organism disposes of malarial pigment indicates that the production of hematin cannot be considered as a normal intermediate process in the formation of bile pigments from hemoglobin.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
74 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献