Affiliation:
1. From the Hospital of The Rockefeller Institute for Medical Research.
Abstract
1. Pneumococci contain an intracellular enzyme of marked lipolytic activity as measured by the acid liberated by its action on tributyrin.
2. Enzyme-containing solutions may be prepared by dissolving pneumococci in bile, or by extraction by other means.
3. The optimum reaction for maximum activity of the endolipase is about pH 7.8, which coincides with the optimum hydrogen ion concentration for growth of pneumococci.
4. Heating the enzyme for 10 minutes at 70°C. destroys its activity.
5. Attenuation of virulence of pneumococcus had no measureable effect on enzyme activity.
6. The possible relation of the endolipase to the mechanism of bile solubility is discussed.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
28 articles.
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1. The Dissimilation of High Molecular Weight Substances;Metabolism;1961
2. Activites Bactériolytiques des Microorganismes;Ergebnisse der Mikrobiologie, Immunitätsforschung und experimentellen Therapie;1957
3. Lipasen;Stoffwechselphysiologie der Fette und Fettähnlicher Stoffe / The Metabolism of Fats and Related Compounds;1957
4. Die Pneumonien;Erkrankungen der Atmungsorgane;1956
5. Antigene;Fortschritte der Serologie;1955