Affiliation:
1. R.B. Hamanaka and N.S. Chandel are at the Division of Pulmonary and Critical Care, Department of Medicine; N.S. Chandel is at the Robert H. Lurie Comprehensive Cancer Center and the Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
Abstract
Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we discuss the benefits that high levels of glycolysis provide for tumor cells, as well as several key enzymes required by cancer cells to maintain this high level of glucose metabolism. It is anticipated that understanding which metabolic enzymes are particularly critical for tumor cell proliferation and survival will identify novel therapeutic targets.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
308 articles.
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