Affiliation:
1. From the Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
Abstract
Fusion of mouse peritoneal macrophages with SV40-transformed human cells, deficient in hypoxanthine guanine phosphoribosyltransferase, resulted in the formation of transformed somatic cell hybrids which contained, without exception, the human chromosome 7 carrying the SV40 genome. It is postulated that the hybridization of mouse nondividing cells with human cancer cells could permit the identification of the human "oncogenic" chromosome(s) present in human cancer cells, since such chromosome(s) should be retained by the totality of the mouse-human hybrid cells.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
138 articles.
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