Personalized cancer T-cell therapy takes the stage, mirroring vaccine success-Reference-Cited by-同舟云学术

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Personalized cancer T-cell therapy takes the stage, mirroring vaccine success

Published:2024-06-11 Issue:8 Volume:221 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Chiffelle Johanna¹²³,Harari Alexandre¹²³^ORCID

Affiliation:

1. Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne University Hospital and University of Lausanne 1 Department of Oncology, , Lausanne, Switzerland

2. Agora Cancer Research Center 2 , Lausanne, Switzerland

3. Center for Cell Therapy, Lausanne University Hospital-Ludwig Institute 3 , Lausanne, Switzerland

Abstract

Personalized T-cell therapy is emerging as a pivotal treatment of cancer care by tailoring cellular therapies to individual genetic and antigenic profiles, echoing the exciting success of personalized vaccines. We describe here the parallel evolution and analogies of cancer vaccines and T-cell therapies.

Publisher

Rockefeller University Press

Link

https://rupress.org/jem/article-pdf/doi/10.1084/jem.20240854/1930421/jem_20240854.pdf

Reference16 articles.

1. Sensitive identification of neoantigens and cognate TCRs in human solid tumors

2. TCR-engineered T cell therapy in solid tumors: State of the art and perspectives

3. Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

4. T cell receptor‐based cancer immunotherapy: Emerging efficacy and pathways of resistance

5. Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

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