Human Mannose-binding Lectin in Immunity-Reference-Cited by-同舟云学术

Human Mannose-binding Lectin in Immunity

Published:2004-05-17 Issue:10 Volume:199 Page:1295-1299
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Casanova Jean-Laurent¹²,Abel Laurent²

Affiliation:

1. Pediatric Hematology-Immunology Unit, Necker Enfants-Malades Hospital,

2. Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes-INSERM U550, Necker Medical School, Paris 75015, France

Abstract

Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/199/10/1295/1126244/jem199101295.pdf

Reference40 articles.

1. Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense

2. Mannose-binding lectin deficiency—revisited

3. Anti-microbial activities of mannose-binding lectin

4. The lectin-complement pathway - its role in innate immunity and evolution

5. The Mannan-Binding Lectin-Associated Serine Proteases (MASPs) and MAp19: Four Components of the Lectin Pathway Activation Complex Encoded by Two Genes

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