Takes one to B1a: Dismantling the origin of mantle cell lymphoma-Reference-Cited by-同舟云学术

Takes one to B1a: Dismantling the origin of mantle cell lymphoma

Published:2021-09-16 Issue:10 Volume:218 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Beaudin Anna E.¹²³^ORCID

Affiliation:

1. Molecular Medicine Program, University of Utah, Salt Lake City, UT

2. Department of Pathology, University of Utah, Salt Lake City, UT

3. Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT

Abstract

Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.

Funder

Pew Charitable Trusts

Hellman Fellows Award

National Heart, Lung, and Blood Institute

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/doi/10.1084/jem.20211482/1422673/jem_20211482.pdf

Reference13 articles.

1. B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production

2. B-cell receptor–driven MALT1 activity regulates MYC signaling in mantle cell lymphoma

3. Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells

4. Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice

5. Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells