THE METABOLISM OF THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL POLIOMYELITIS

Author:

Racker E.1,Kabat Herman1

Affiliation:

1. From the Anderson Institute for Biological Research and the Department of Physiology, University of Minnesota, Minneapolis

Abstract

1. During paralysis, the brain of the mouse infected with poliomyelitis virus shows on test after mincing a decrease in anaerobic glycolysis with no significant change in oxygen utilization. The decrease in anaerobic glycolysis varies from 5 per cent to 50 per cent. 2. Sodium fluoride produces a greater inhibition of anaerobic glycolysis in normal than in poliomyelitic brain. 3. Dehydrogenase activity is higher for poliomyelitis-infected brain without added substrate. This difference from normal disappears when substrates are added. 4. The ratio of See PDF for Equation for the sliced motor cortex is higher than for sliced visual cortex of the dog and cat. 5. The oxygen consumption of the anterior horn of the sliced spinal cord of dog and cat is much less than that of the cerebral cortex. 6. The findings are in keeping with the view that, at a certain stage of the infection, the nerve cells may be reversibly injured but not yet destroyed by the virus.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 25 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Chapter 5 Efraim Racker: 28 June 1913 to 9 September 1991;Selected Topics in the History of Biochemistry Personal Recollections. V;1997

2. THE THIRD FEODOR LYNEN LECTURE: MY LIFE AND CARBON DIOXIDE FIXATION;The Molecular Basis of Biological Transport;1972

3. Metabolic Effects of Intracellular Infections in Man;Annals of Internal Medicine;1967-10-01

4. Biochemistry of Animal-adapted Poliomyelitis Infection in vivo;The Biochemistry of Poliomyelitis Viruses;1964

5. RESPIRATION AND GLYCOLYSIS DURING INFECTION WITH POLIOMYELITIS VIRUS;Problems of the Biochemistry of the Nervous System;1964

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3