Author:
Platzer E,Welte K,Gabrilove J L,Lu L,Harris P,Mertelsmann R,Moore M A
Abstract
We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation-inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
143 articles.
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