Author:
Kirkman R L,Barrett L V,Gaulton G N,Kelley V E,Ythier A,Strom T B
Abstract
Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
204 articles.
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