Double Heterozygotes for the Ashkenazi Founder Mutations in BRCA1 and BRCA2 Genes

Author:

Friedman Eitan,Bar-sade Bruchim Revital,Kruglikova Anna,Risel Shulamit,Levy-Lahad Ephrat,Halle David,Bar-On Elchanan,Gershoni-Baruch Ruth,Dagan Ephrat,Kepten Ilana,Peretz Tamar,Lerer Israela,Wienberg Naomi,Shushan Asher,Abeliovich Dvorah

Publisher

Elsevier BV

Subject

Genetics (clinical),Genetics

Reference10 articles.

1. The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women;Abeliovich;Am J Hum Genet,1997

2. A human BRCA1 gene knockout;Boyd;Nature,1995

3. The 185delAG BRCA1 mutation originated before the dispersion of Jews in the Diaspora and is not limited to Ashkenazim;Bruchim Bar-Sade;Hum Mol Genet,1998

4. Co-segregation of BRCA1 185delAG mutation and BRCA2 6174delT in one single family;Gershoni-Baruch;Eur J Cancer,1997

5. Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and breast-ovarian cancer families;Levy-Lahad;Am J Hum Genet,1997

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