Causation and Single Nucleotide Polymorphism Heritability

Author:

Bourrat Pierrick

Abstract

Genome-wide association studies (GWAS) of human complex traits have provided us with new estimates of heritability. These estimates foreground the question of genetic causation. After having presented in simple terms the rationale underlying this way of estimating heritability, I assess the extent to which relationships between genes and phenotypes established with GWAS satisfy several dimensions of causal relationships—namely, range of influence, specificity, and stability—distinguished within the interventionist account of causation. The upshot is that if these relationships are causal in some sense, my analysis shows the extent to which they do not represent paradigmatic causal relationships.

Publisher

Cambridge University Press (CUP)

Subject

History and Philosophy of Science,Philosophy,History

Cited by 12 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A Wolf in Sheep's Clothing: Idealisations and the aims of polygenic scores;Studies in History and Philosophy of Science;2023-12

2. Polygene Risk Scores;Philosophy of Medicine;2023-07-05

3. Genetically caused trait is an interactive kind;European Journal for Philosophy of Science;2023-07-01

4. Heritability and Etiology: Heritability estimates can provide causally relevant information;Personality and Individual Differences;2023-01

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