Systemic Treatment After Locoregional Recurrence in Breast Cancer: A Review

Abstract

Locoregional recurrence (LRR) in breast cancer poses significant challenges due to its association with biologically resistant disease and a high likelihood of concurrent occult systemic disease. Despite advancements in local and systemic therapies, LRR affects a substantial percentage of patients, leading to poorer prognosis compared to those with primary breast cancer. Therefore, a comprehensive review of systemic treatment strategies following LRR is warranted to address the gaps in our understanding and improve patient outcomes. This review explored factors influencing the prognosis of breast cancer LRR. In particular, we evaluated the benefits of systemic treatment options post-resection and proposed an optimal treatment algorithm.