Palladium(II) Complexes with S-Benzyl Dithiocarbazate: Synthesis, Characterization in vitro Antimicrobial and Anticancer Activities

Abstract

Square planar complexes of palladium(II) were prepared by the reaction of PdCl2 with four different thio Schiff bases, namely 2-acetyl-pyridine S-benzyl dithiocarbazate (L1H), 2-acetylthiophene-S-benzyl dithiocarbazate (L2H), 2-acetylfuran-S-benzyl dithiocarbazate (L3H) and 2- acetylnaphthalene-S-benzyl dithiocarbazate (L4H) in a 1:2 molar ratio. Elemental analysis, molecular weight determinations, conductance measurements and spectral data, including electronic, IR, 1H and 13C NMR and X-ray powder diffraction studies, confirmed the formation of palladium(II) complexes. The electrochemical behaviour of one of the palladium(II) complex has also been determined by cyclic voltammetry. The antimicrobial activities of the Schiff base ligands and their corresponding palladium(II) complexes have been tested in vitro against various pathogenic bacterial and fungal strains. The cytotoxicity of [Pd(L1)2] complex shows the promising results when analyzed using MTT cell proliferation assay.