Synthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1'-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes-Reference-Cited by-同舟云学术

Synthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1'-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes

Published:2019-02-27 Issue:4 Volume:31 Page:799-804
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Kumar Manoj¹,Pallvi ¹,Tuli Hardeep Singh²,Khare Rajshree³

Affiliation:

1. Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134007, India

2. Department of Biotechnology, Maharishi Markandeshwar University (Deemed to be University), Mullana-Ambala-133207, India

3. Department of Chemistry, Maharishi Markandeshwar University (Deemed to be University), Mullana-Ambala-133207, India

Abstract

Novel Schiff base and its two transition metal complexes derived from the condensation reaction of 2,6-diacetylpyridine with biguanide, characterized by 1H NMR, IR and elemental analysis. The ligand and its cobalt(II) and nickel(II) complexes showed potent DNA photo-cleavage activity. Antimicrobial activity of this Schiff base and its cobalt(II) and nickel(II) complexes against bacteria and fungi viz. S. aureus, K. pneumoniaae and A. niger, Trichophyton rubrum, respectively was evaluated in terms of zone of inhibition.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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