Oxidation of Cinacalcet Hydrochloride by Chloramine-B in Acid Medium: A Kinetic and Mechanistic Study-Reference-Cited by-同舟云学术

Oxidation of Cinacalcet Hydrochloride by Chloramine-B in Acid Medium: A Kinetic and Mechanistic Study

Published:2021 Issue:9 Volume:33 Page:2065-2068
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Kallesha Nichhapurada¹^ORCID,Prasad Ningegowda²,Shivakumara N.³^ORCID,Narasimhamurthy Kereyagalahally H.⁴^ORCID

Affiliation:

1. Department of Chemistry and Research Center, Vidya Vikas Institute of Engineering & Technology (Affiliated to Visvesvaraya Technological University, Belagavi), Mysuru-570028, India

2. Department of Chemistry, Government Engineering College (Affiliated to Visvesvaraya Technological University, Belagavi), Chamarajanagara-571313, India

3. Department of Chemistry, Ramaiah Institute of Technology, Bangalore-560054, India

4. Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India

Abstract

Kinetic and mechanistic study of cinacalcet hydrochloride by chloramine-B (CAB) in HCl medium at 308 K was the aim of this work. Analyzed the reaction at five different temperatures and determined the thermodynamic parameters using Arrhenius plots. The reaction had a stoichiometry of 1:2 and characterized the oxidation product using chromatographic and spectroscopic methods. The rate law is deduced from the marked effects, which were accompanied by plausible mechanisms.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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