Synthesis and Antibacterial Investigation of Mn(II) and Co(II) Complexes of Schiffs Base Ligand

Abstract

Complexes of chlorides and acetates of Mn(II) and Co(II) with ligand, 3-[mercapto-[1,3,4]thiadiazol-2-ylimino)-methyl]-benzene-1,2-diol has been synthesized and characterized. The metal complexes so formed were characterized by molar conductance, elemental analysis, mass, EPR, IR and electronic spectral studies. Geometry of the ligand and its metal complexes was optimized by (B3LYP) functional with 6-31G (d,p) basis sets method of the Gaussian 09 W. All the metal complexes were found to be non-electrolytes. Metal complexes are represented as [M(L)2X2] [where L = Schiffs base ligand, M = Mn(II), Co(II) and X = Cl–, CH3COO–]. Octahedral geometry for Mn(II) and Co(II) complexes was determined by means of spectral studies and molecular modelling. Ligand and its metal complexes were screened against three bacteria- P. aeruginosa, S. pyogens and B. subtilis using well diffusion method. Complexes are found to be more potent as compare to the ligand.