Neurofilament heavy chain gene polymorphism and risk of multiple sclerosis-Reference-Cited by-同舟云学术

Neurofilament heavy chain gene polymorphism and risk of multiple sclerosis

Published:2020-12-29 Issue:4 Volume:22 Page:155-158
ISSN:2717-0071
Container-title:Journal of Shahrekord University of Medical Sciences
language:en
Short-container-title:J Shahrekord Univ Med Sci

Author:

Ghorbani Jazar Elham¹^ORCID,Chavoshi Tarzjani Seyedeh Parisa²^ORCID,Sadeghi Zahra²^ORCID,Alaie Shekoofe³^ORCID,Shahzadeh Fazeli Seyed Abolhassan¹⁴^ORCID

Affiliation:

1. Departments of Molecular and Cellular Biology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran

2. Department of Genetics, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran

3. Neurologist, Member of Iranian Multiple Sclerosis Society, Tehran, Iran

4. Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

Abstract

Multiple sclerosis (MS) is a chronic disease characterized by degeneration of the central nervous system (CNS). High levels of Neurofilament heavy chain (NEFH) in cerebrospinal fluid (CSF) is associated with MS. 40 MS patients and 40 controls genotyped by polymerase chain reaction (PCR) and Sanger sequencing. Genotypic and allelic distributions were compared between cases and controls. Fisher test was used to estimate the risk of MS associated with genotypes. We showed that NEFH, 1084-244G>A gene polymorphism, has no significant association with the susceptibility or severity of MS in Iranian patients (P = 0.737). Further prospective studies are required for confirmation.

Publisher

Maad Rayan Publishing Company

Link

http://j.skums.ac.ir/PDF/jskums-22-155.pdf

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